Mole Tar Can
نویسنده
چکیده
Download cell division cycle 7 (Cdc7) is a serine-threonine kinase, originally discovered in budding yeast, ed to initiate DNA replication. Human Cdc7 phosphorylates the minichromosome maintenance n 2 (Mcm2), a component of the DNA replicative helicase needed for genome duplication. Inhibif Cdc7 in cancer cells impairs progression through S phase, inducing a p53-independent apoptotic ath, whereas in normal cells, it does not affect cell viability. Small molecule compounds able to re with Cdc7 activity have been identified and shown to be effective in controlling tumor growth in l models. Two Cdc7 inhibitors are currently in phase I clinical development. Inhibition of Cdc7 anima kinase activity in cancer cells restricts DNA replication and induces apoptotic cell death by an unprecedented molecular mechanism of action. Clin Cancer Res; 16(18); 4503–8. ©2010 AACR.
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